Abstract
Takotsubo cardiomyopathy is an acute stress-induced heart failure syndrome for which the exact pathogenic
mechanisms are unclear, and consequently, no specific treatment exists. In an experimental model of stressinduced
takotsubo-like cardiomyopathy, the authors describe the temporal course of a chronic inflammatory
response post-induction, with an initial early influx of neutrophils into myocardial tissue followed by macrophages
that are typical of a proinflammatory M1 phenotype, and a nonsignificant increase in systemic
inflammatory cytokines. Post-mortem myocardium from the more complex clinical takotsubo patients share
features of the study's experimental model. These findings suggest modulators of inflammation could be
a potential therapeutic option. (J Am Coll Cardiol Basic Trans Science 2018;3:766-78) © 2018 The Authors.
Published by Elsevier on behalf of the American College of Cardiology Foundation.
Year
2018
Category
Refereed journal