Document details for 'Efficacy of Bilberry and Grape Seed Extract Supplement Interventions to Improve Glucose and Cholesterol Metabolism and Blood Pressure in Different Populations-A Systematic Review of the Literature'

Authors Grohmann, T., Litts, C., Horgan, G.W., Zhang, X., Hoggard, N., Russell, W. and de Roos, B.
Publication details Nutrients 13, 1692. MDPI (Multidisciplinary Digital Publishing Institute).
Publisher details MDPI (Multidisciplinary Digital Publishing Institute)
Keywords bilberry; grape seed; extracts; glucose; cholesterol; systolic; diastolic; human intervention studies.
Abstract Abstract: Previous studies found that intervention with fruit extracts rich in flavonoids can de-crease levels of blood glucose, cholesterol, and blood pressure. In this study we set out to critical-ly review the efficacy by which bilberry and grape seed extracts affect these outcomes, and whether factors such as health status, age, intervention dose and duration may affect respon-siveness. Through a systematic literature search we identified 22 eligible intervention studies, 4 with bilberry and 18 with grape seed extract. We found that bilberry extract lowered average lev-els of HbA1c by 4.7% in an older Chinese population diagnosed with T2DM. Additionally, chronic interventions had a larger impact on glucose metabolism markers compared to short-term interventions. Interventions with both grape seed and bilberry extracts lowered total and LDL cholesterol levels by up to 4 and 10%, respectively, irrespective of the participants' health condition and other study characteristics. Intervention with grape seed extract also led to significant reductions in systolic and diastolic blood pressure of 5% and 4%, respectively, in hy-pertensive subjects, but also in healthy individuals and those diagnosed with metabolic syn-drome. In conclusion bilberry extract appears to lower blood glucose, while grape seed extract could be considered a potential substitute for blood pressure drugs in mild hypertension. We observed that the responsiveness to the treatments could be dependent on pre-existing health conditions, and chronic interventions appear to be more beneficial for blood glucose metabolism in comparison to short-term interventions. (currently 255 words, should be 200 words)
Last updated 2021-05-17

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