Human Health & Nutrition

Microarray studies of weight regulation

Plot of estimated expression ratios

The Siberian hamster, which is used as a model for weight regulation in humans, is known to adapt its body weight according to season, and shows big weight changes between in summer-like long day (LD) and winterlike short day (SD) photoperiods. Identification of genes contributing to the seasonal-appropriate body weight of the Siberian hamsters may provide an insight into how body weight is regulated in other mammals including humans. BioSS helped with normalisation of cDNA microarrays and analyses based on significance tests, controlling the false discovery rate, to find genes that were differentially expressed in hypothalamic samples from animals living under LD and SD conditions.

Plot of estimated expression ratios (LD to SD). Horizontal lines indicate 0 (solid) and 2-fold (dashed) expression ratios. Coloured spots indicate genes with strongest evidence for differential expression. Vertical line indicates cut-off for background noise.

Further details from: Claus-Dieter Mayer

Article date 2007

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Human Health & Nutrition