Genetic Networks from Pairwise Mutual Information Scores

© Copyright 2003

Dirk Husmeier
Biomathematics and Statistics Scotland (BioSS)
JCMB, The King's Building, Edinburgh EH9 3JZ, United Kingdom

Preliminaries

MutInf is a free MATLAB software package to infer genetic networks from pairwise mutual information scores. It is based on the ideas presented in the following paper:

Butte AS, Kohane IS (2000)
Mutual information relevance networks: functional genomic clustering using pairwise entropy measurements
Pacific Symposium on Biocomputing 5, 418-429

Note that this software package was developed solely as a model exploration tool, and it is provided without guarantee of maintenance or support, and without warranty. The copyright holder is not liable for any damages which may result in any manner from the use of this software.

Download the software

To obtain the software, click here. This will give you a gzipped TAR file called MutInf.tar.gz. To extract this file under UNIX, proceed as follows:

gunzip MutInf.tar.gz
tar xvf MutInf.tar

You can now delete the TAR file:

rm MutInf.tar

Make sure you add the directory with the programs to you MATLAB path. You can do this from the MATLAB prompt as follows:

New_HOME='XXX';
eval(sprintf('addpath ''%s'' ', New_HOME));

where XXX is the name of the directory in which you keep the programs.

Program files

Information about each function is obtained by typing help plus the function name (without the extension ".m") at the MATLAB prompt. Example:

help MutualInfo

Getting started

To get started, go through the following three worked examples.
You can also test the software on my genetic network simulator.