Detecting recombination and rate variation
in DNA sequence alignments
One-year MRes project
Student:
Ming Tso Chiang
BioSS Supervisor:
Dirk Husmeier
University Supervisor:
Douglas Armstrong
General comments
Objective of the project
Recommended courses
Recommended conference to attend
Learn to work independently
Hidden Markov Models (HMMs)
Milestone 1: Introduction to HMMs
(First half of October 2003)
Milestone 2: Viterbi algorithm
(Second half of October 2003)
Milestone 3: Learning parameters from complete data
(First half of November 2003)
Milestone 4: Forward-backward algorithm
(Second half of November 2003)
Milestone 5: Learning parameters from incomplete data with the Baum-Welch algorithm
(First half of December 2003)
Phylogenetics
Milestone 6: Introduction to phylogenetics
(January-February 2004)
Milestone 7: Combining phylogenetic trees with hidden Markov models for detecting recombination - Maximum likelihood
(March 2004)
Midproject review
Milestone 8: Combining phylogenetic trees with hidden Markov models for detecting recombination - Bayesian approach (MCMC)
(April 2004)
Milestone 9: Combining phylogenetic trees with hidden Markov models for modelling rate variation
(May 2004)
Milestone 10: Factorial hidden Markov model for distinguishing between recombination and rate variation
(June-August 2004)
Writing up of thesis (September-October 2004)
Last update: May 2003.