||Cadmium (Cd) is a toxic metal that can be relatively high in brown meat from crab and there is concern that it
may accumulate in long-term crabmeat consumers posing a health risk. Sixteen healthy habitual crabmeat
consumers and twenty five healthy non-crabmeat consumers were recruited through completion of a seafood
frequency questionnaire. Whole blood and urine samples were analysed for Cd levels and urinary beta-2-microglobulin,
an established marker of Cd-induced kidney toxicity, to determine levels in crabmeat consumers.
Whole blood Cd levels were significantly elevated in the crabmeat-consuming group, whereas urinary levels of
Cd and beta-2-microglobulin were not. Whole blood Cd levels can be both a short and long-term marker for Cd
intake and levels might be expected to be elevated in the crabmeat consumers as crabmeat can contain Cd.
However, crabmeat consumers did not show increases in a more established long-term marker of Cd (urinary Cd)
and consistent with this, no change in a Cd-induced kidney toxicity marker. Consequently, in conclusion,
compared to consumers who reported very little crabmeat consumption, healthy middle-aged consumers who
regularly consume brown crabmeat products (an average of 447 g/week) for an average of 16 years showed no
change in long-term Cd exposure or kidney toxicity.