Royal Statistical Society
Highlands Local Group


Local organising Committee

 

Graeme MacLennan (Chair)
Health Services Research Unit
Foresterhill
Aberdeen AB25 2ZD
Dr Lorna Aucott (Hon Secretary)
Polwarth Building,
Forresterhill,
Aberdeen AB25 2ZD 
Phone: +44 (0) 1224 553809 Phone: +44 (0) 1224 876544  

Next meeting:


We are delight to be able to take advantage of Elizabeth Thompson who has been visiting here in Scotland for a little while. She has agreed to come up to Aberdeen to give us an RSS Local Highland Group meeting talk

DATE: Wednesday 28th June 2017
SPEAKER: Prof Elizabeth Thompson, University of Washington
TIME: 16:00
VENUE: Macaulay B Lecture Theatre, James Hutton Institute, Aberdeen
TITLE: "Mapping causal DNA through the shared descent of genome in population samples"


ABSTACT
The relatedness of individuals is reflected in the close similarity of their DNA that is descended from shared common ancestors. Genome descends and functions in segments; models and methods for the detection of shared segments of genome can greatly increase accuracy. Modeling the dependence in the DNA both among individuals and across genome locations is key to using modern genomic data in the mapping the locations of DNA that contribute to a quantitative trait. With modern genetic marker (SNP) data, we can estimate pairwise proportions of genome shared both at specific genome locations and globally across the genome, without the need for prior information on pedigree relationships. We present models for using estimated genome sharing in gene mapping, and also show how Kullback-Leibler information can be used to provide a more reliable assessment of the meaning of a linkage signal in ascertained samples. Additionally, genome descends jointly to current members of a population: pairwise analyses lose information. I will present some recent approaches to estimation of the joint patterns of shared genome segments among multiple individuals and indicate how this additional information can be important in gene mapping.

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