Royal Statistical Society
Highlands Local Group


Local organising Committee

 

Dr Claus Mayer (Chair)
Biomathematics & Statistics Scotland
Foresterhill
Aberdeen AB25 2ZD
Dr David McLernon (Hon Secretary)
Polwarth Building,
Forresterhill,
Aberdeen AB25 2ZD 
Phone: +44 (0) 1224 438652 Phone: +44 (0) 1224 437152  

We are delighted to announce that the next Joint RSS Highland Local Group / St Andrews meeting will take place on 5th June. Please see the details below. Further information will be announced in due course.

Date: Wednesday 5th June 2019

Time: 2-5pm

Venue: Physics Lecture Theatre C, St Andrews University

Speakers: Theresa Smith (Bath) and Ruwanthi Kolamunnage-Dona (Liverpool)

Abstracts

Theresa Smith, Bath

Title: A stratified age-period-cohort model for spatial heterogeneity in all-cause mortality

Summary: A common goal in modelling demographic rates is to compare two or more groups. For example comparing mortality rates between men and women or between geographic regions may reveal health inequalities. A popular class of models for all-cause mortality as well as incidence of specific diseases like cancer is the age-period-cohort (APC) model. Extending this model to the multivariate setting is not straightforward, because the univariate APC model suffers from well-known identifiability problems. Often APC models are fit separately for each stratum, and then comparisons are made post hoc. A stratified APC model is introduced to directly assess the sources of heterogeneity in mortality rates using a Bayesian hierarchical model with matrix-normal priors that share information on linear and nonlinear aspects of the APC effects across strata. Computing, model selection, and prior specification are addressed and the model is then applied to all-cause mortality data from the European Union.

Ruwanthi Kolamunnage-Dona

Title: Joint modelling of longitudinal data and event-times with applications in health research

Abstract: Joint modelling of longitudinal data and event-time processes has gained its popularity in last decade as they yield more accurate and precise estimates. However, adopting this framework in health research has been limited. For example, in many clinical trials with longitudinal outcome data, a common situation is where some patients withdraw or dropout from the trial before completing the measurement schedule but the dropout may be non-ignorable. In such cases, the longitudinal outcome data alone may not reflect a genuine change over time, it may be an artefact caused by selective dropout, which could result in a biased comparison between the treatment groups. In other research, a relatively large number of quantities such as biomarkers are measured over patientsí follow-up over time to fully explore the damage caused by adverse clinical events, and harnessing all such information in a single model could lead to improved estimation and prediction. In this talk, the methodology of joint modelling and its advances for competing risks and multiple longitudinal outcomes will be discussed with real applications in health research.


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